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A Report of the First 50 Dual Kidney Transplants at Stanford University

Amy D. Lu, MD, MPH; Jonathan T. Carter; Rebecca J. Weinstein; Wijan Prapong, BS; Oscar Salvatierra, MD; Donald C. Dafoe, MD; Edward J. Alfrey, MD

Arch Surg. 1999;134:971-976.

Hypothesis  Recipients of dual kidney transplants from older expanded criteria donors (ECDs) have outcomes similar to recipients of single kidneys from younger donors. Dual transplantation is the use of both adult donor kidneys into a single adult recipient.

Design  Donor and recipient variables were entered into a database. Analysis was performed in a retrospective fashion. The unpaired t test and ² test were used as appropriate.

Setting  A university teaching hospital.

Patients  All adult recipients of cadaveric kidney-only transplants from adult donors between November 1991 and January 1999. Patients were grouped based on whether they received a dual or single transplant and whether the donor was an ECD. The control group of patients received non-ECD cadaveric kidneys.

Results  Donors for recipients of dual kidneys were older and had a lower creatinine clearance on hospital admission than recipients of single control kidneys. Recipients of dual transplants were older, had fewer rejections, and had similar 3-month and 1-year serum creatinine levels vs controls. Predictors of an elevated serum creatinine level or graft loss at 3 months in recipients of ECD dual and single transplants included kidneys from donors with unstable preprocurement renal function, and recipients who developed delayed graft function.

Conclusion  Recipients of dual kidney transplants from ECDs have excellent outcomes similar to recipients of single control kidneys.

From the Department of Surgery, Stanford University, Stanford, Calif.

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