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Alan P. B. Dackiw, MD, PhD; Jeffrey J. Sussman, MD; Herbert A. Fritsche, Jr, PhD; Ebrahim S. Delpassand, MD; Pam Stanford, RN; Ana Hoff, MD; Robert F. Gagel, MD; Douglas B. Evans, MD; Jeffrey E. Lee, MD

Arch Surg. 2000;135:550-557.

Hypothesis  Technetium Tc 99m sestamibi scintigraphy, intraoperative gamma probe detection, and the rapid parathyroid hormone assay have been used to permit a directed operation in patients with hyperparathyroidism. We hypothesized that the coordinated use of these techniques might be particularly useful in patients who require a second operation for hyperparathyroidism.

Design  Retrospective analysis was performed to determine the specific contribution of these technologies to the surgical management of patients with hyperparathyroidism who underwent evaluation by at least 2 of these techniques between April 1996 and October 1999.

Setting  Patients were evaluated and treated by an endocrine tumor surgery group within a tertiary care referral center.

Patients  Coordinated application of ^99mTc-sestamibi scintigraphy, intraoperative gamma probe detection, and/or the rapid parathyroid hormone assay was performed in 32 patients.

Results  Twenty-eight of 32 patients had primary hyperparathyroidism, 3 had multiple endocrine neoplasia type 1, and 1 had secondary hyperparathyroidism. The surgical procedure was an initial cervical exploration in 19 and a second operative procedure in 13. Parathyroidectomy was successful in all patients. A directed anatomic operation was performed in 24 patients, including 11 patients who underwent second operative procedures and 9 patients who underwent minimally invasive procedures under local anesthesia. A directed operation was facilitated by sestamibi scan in 22 of 24 patients, intraoperative gamma probe detection in 5 of 23 patients, and the rapid parathyroid hormone assay in 15 of 15 patients.

Conclusions  Coordinated application of ^99mTc-sestamibi scintigraphy, intraoperative gamma probe detection, and the rapid parathyroid hormone assay allows for successful directed reoperative parathyroidectomy; a minimally invasive procedure may be performed in selected patients.

From the Departments of Surgical Oncology (Section of Endocrine Tumor Surgery), Research Laboratory Medicine, Nuclear Medicine, and Medical Specialties (Section of Endocrine Neoplasia and Hormonal Disorders), The University of Texas M. D. Anderson Cancer Center, Houston; and the Division of Surgical Oncology, University of Cincinnati Medical Center, Cincinnati, Ohio.

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