This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (2)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Breast Cancer  • Surgical Oncology  • Drug Therapy  • Drug Therapy, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Baiba J. Grube, MD, MS; Carla J. Christy, MD; Dalliah Black, MD; Maritza Martel, MD; Lyndsay Harris, MD; Joanne Weidhaas, MD, PhD; Michael P. DiGiovanna, MD, PhD; Gina Chung, MD; Maysa Mahmoud Abu-Khalaf, MD; Kenneth D. Miller, MD; Susan A. Higgins, MD, MS; Liane Philpotts, MD; Fattaneh A. Tavassoli, MD; Donald R. Lannin, MD

Arch Surg. 2008;143(7):692-700.

Hypothesis  Timing of sentinel lymph node dissection (SLND), before or after preoperative chemotherapy (PC), for breast cancer is controversial.

Design  Single-institution experience with SLND before PC.

Setting  Data from prospectively collected Yale-New Haven Breast Center Database.

Patients  Fifty-five SLNDs were performed before PC for invasive breast cancer in clinically node-negative patients between October 1, 2003, and September 30, 2007. The results are compared with patients who underwent SLND and definitive breast and axillary surgery before chemotherapy (control group; n = 463 SLNDs).

Interventions  If sentinel nodes (SNs) were negative before PC, no axillary lymph node dissection (ALND) was performed. If SNs were positive, ALND was performed after PC at the time of definitive breast surgery.

Main Outcome Measures  Sentinel node identification rate, false-negative rate, rate of positivity, and rate of residual disease in axilla.

Results  Of the 55 SLNDs performed before PC, 30 (55%) had a positive SN. The SN identification rate was 100% and the clinical false-negative rate was 0%. In the control group of those with a positive SN, 55% (56 of 101 patients) had no additional positive nodes, 25% (25 of 101) had 1 to 3 positive nodes, and 20% (20 of 101) had 4 or more positive nodes. In the group with a positive SN before PC, 69% (18 of 26 patients) had no additional positive nodes after PC, 27% (7 of 26) had 1 to 3 nodes, and 4% (1 of 26) had 4 or more nodes. Among the SN-positive patients, a pathologic complete response in the breast was found in 4 of 18 patients who had a tumor-free axilla after PC.

Conclusions  Sentinel lymph node dissection before PC allows accurate staging of the axilla for prognosis and treatment decisions. Despite downstaging by PC, a significant percentage of patients had residual nodal disease in the axillary dissection.

Author Affiliations: Departments of Surgery (Drs Grube, Christy, Black, and Lannin), Pathology (Drs Martel and Tavassoli), Medical Oncology (Drs Harris, DiGiovanna, Chung, Abu-Khalaf, and Miller), Therapeutic Radiology (Drs Weidhaas and Higgins), and Radiology Breast Imaging (Dr Philpotts), Yale University School of Medicine, New Haven, Connecticut.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?