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J. Thomas Grayston, MD

Arch Surg. 1999;134:930-934.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

This presentation will be in 3 parts. First, there will be an introduction to the microbiology and epidemiology of Chlamydia pneumoniae. I will then present the data that establish an association between C pneumoniae and atherosclerosis, and finally, I will discuss some of the preliminary data concerning a causal role for C pneumoniae and atherosclerosis.

C PNEUMONIAE, A NEWLY DESCRIBED SPECIES OF THE GENUS CHLAMYDIA

History

We isolated the prototype C pneumoniae strain, TW-183, in 1965, but its role in respiratory infection was not demonstrated until the 1980s.^1-2 The laboratory designation of the first isolate from respiratory disease was AR-39 and led to the strain name TWAR (from the TW + AR of the first 2 isolates). In 1989, based on DNA homology and morphology of the elementary body, the TWAR organism was established as a new third species of the genus Chlamydia and named C pneumoniae after the most commonly recognized clinical syndrome associated with . . . [Full Text of this Article]

Microbiology

Epidemiology

OBSERVATIONAL STUDIES PROVE THE ASSOCIATION OF C PNEUMONIAE AND ATHEROSCLEROSIS

Seroepidemiologic Study

Direct Demonstration of C pneumoniae in Atherosclerotic Lesions

ETIOLOGIC STUDIES

Animal Models

Mechanisms

Antibiotic Treatment Trials

Retrospective Studies.

Prospective Studies.

CONCLUSIONS

From the Department of Epidemiology, University of Washington, Seattle.

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