 |
|
Lack of Evidence for Adrenal Insufficiency After Single-Dose Etomidate—Reply
Bryan A. Cotton, MD;
Oscar D. Guillamondegui, MD
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
In reply
We would like to thank Drs Mullins and Theodoro for their comments and interest in on our recent article.1 There are several statements, however, that need to be addressed.
The authors question the internal validity of the study design. Internal validity errors concern instances in which a study design fails to address the narrowest of research questions. We feel the basic study question was answered and clearly stated in the introduction.
As to "obvious selection bias" of studying only those with suspected AI, we would agree and this was addressed in our study limitations. However, we were not evaluating cosyntropin unresponsiveness but rather the presence of clinically relevant AI that warranted intervention. In fact, cosyntropin unresponsiveness (in the absence of hemodynamic issues) has been shown not to correlate with outcome.2 Therefore, it appears relevant that we selected those patients in . . . [Full Text of this Article]
AUTHOR INFORMATION
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
Increased Risk of Adrenal Insufficiency Following Etomidate Exposure in Critically Injured Patients
Bryan A. Cotton, Oscar D. Guillamondegui, Sloan B. Fleming, Robert O. Carpenter, Shivani H. Patel, John A. Morris, Jr, and Patrick G. Arbogast
Arch Surg. 2008;143(1):62-67.
ABSTRACT
| FULL TEXT
RELATED LETTER
Lack of Evidence for Adrenal Insufficiency After Single-Dose Etomidate
Michael E. Mullins and Daniel L. Theodoro
Arch Surg. 2008;143(8):808-809.
EXTRACT
| FULL TEXT
|
