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Test Before You Stop—Reply
James M. O’Riordan, MD;
Ronan J. Margey, MB;
Gavin Blake, MD;
P. Ronan O’Connell, MD
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In reply
We thank Drs Kumar and Roberts for their comments and interest in our article. Bedside platelet function testing could potentially provide the surgeon with a useful adjunct in treating patients taking antiplatelet agents in the perioperative period owing to variability between patients with regard to antiplatelet inhibition. However, platelet activation and aggregation involve multiple agonists and pathways, and the currently available laboratory-based techniques and bedside tests (eg, VerifyNow) used to assess platelet aggregation examine only 1 agonist and 1 pathway at a time. The criterion standard for assessing platelet aggregation remains light transmission aggregometry,1 which is time-consuming, expensive, and does not take place at the bedside. Therefore, basing clinical judgments on the outcomes of a single platelet aggregation assay, in its current format, could potentially lead to inappropriate decision-making. In the future, we . . . [Full Text of this Article]
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RELATED LETTER
Test Before You Stop
Abhishek Kumar and David H. Roberts
Arch Surg. 2009;144(8):787.
EXTRACT
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RELATED ARTICLE
Antiplatelet Agents in the Perioperative Period
James M. O’Riordan, Ronan J. Margey, Gavin Blake, and P. Ronan O’Connell
Arch Surg. 2009;144(1):69-76.
ABSTRACT
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