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Arch Surg. 2009;144(9):878.

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Answer: Osteoclast Giant Cell Tumor of the Pancreas

Among cancers of the gastrointestinal tract, pancreatic adenocarcinoma is the third most common malignancy and the fifth leading cause of cancer-related mortality. We describe a rare case of a 63-year-old woman with an osteoclast giant cell tumor of the pancreas (OGTP). The incidence of this tumor encompasses less than 1% of nonendocrine pancreatic cancers, with the most prevalence in the sixth or seventh decade of life and an equal sex ratio.¹ The most common presenting symptoms include vague abdominal pain, weight loss, jaundice, and a palpable abdominal mass. The only published data regarding this rare malignancy are in the context of case reports. Giant cell tumor of the pancreas is a very rare neoplasm and appears as 2 different phenotypes, undifferentiated carcinoma and OGTP, each with its own histiogenesis.² Undifferentiated giant cell tumor has an epithelial origin and demonstrates more pleomorphic and anaplastic features. There is controversy in the literature . . . [Full Text of this Article]

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